The College is made up of four divisions (the Division of Humanities, the Division of English Language, and the Division of Education, and the Division of Culture and Tourism) which offer a total of thirteen majors.

Starting as the Division of Science in 1948, the College is presently comprised of three divisions offering eight majors and two departments. The Division of Natural Science offers majors in Physics, Chemistry and Biology, while the Division of Mathematics & Statistics is made up of majors in Mathematics and Statistics. Following the academic exchange agreement with the Korean Advanced Institute of Science and Technology (KAIST) in 1994, the College has been engaged in joint research, faculty exchanges and joint utilization of experimental facilities. The Division of Computer & Information Science was established in 1998 to produce leading personnel in the information society by offering majors in Computer Science and Multimedia. Meanwhile, the Departments of Physical Education and Dance train professionals in these respective fields.

Founded over 60 years ago, the College was a pioneer in Korean life-science education. Originally the Department of Home Economics in Sookmyung Women's Junior College in 1938, it is now the College of Life Science and offers a total of four majors.

Sookmyung College of Law prepares students for success in law practices, business, public service and various social fields, introducing well-trained women leaders into Korea and into global society. To achieve these valuable goals, Sookmyung College of Law provides innovative curriculum linking the humanities and social sciences with the study of legal knowledge. Furthermore, Sookmyung College of Law offers unparalleled opportunities for clinical training and strongly encourages public service in an energetic and creative learning environment. SM College of Law's outstanding faculty, students and alumni all contribute to its leadership role in Korea and international legal education.

Originated in the early 1950s, the College of Economics and Business Administration is the home of higher learning, research and leadership for faculty, students and alumni. Currently, the College is comprised of two divisions: the Division of Economics and the Division of Business Administration. The curriculum integrates innovative methods in teaching and research and develops leadership potential for the global economy.

Since starting as the Department of Pharmacy in 1952, the College has produced over 3,700 pharmacists. In 1997 the College of Pharmacy was selected as the best college in its field Korea-wide in an evaluation performed by the Korean University Education Board. The College has also introduced a distance learning system over the Internet to cultivate specialists.

The School of Global Services offers a Bachelor of Arts degree in International Development Studies and that in Entrepreneurial Studies. One of the most distinctive feature is that all freshmen are required to take the Self Career Management class, to assist themselves in their career selection after graduation. The Global Cooperation program also provides female students who possess high linguistic ability and cultural sensitivity, with the appropriate knowledge, skills, and values necessary for advancement in careers in a global organization or a multinational cooperation. Meanwhile, the Entrepreneurship program is designed to prepare female students—educated in both theory and application and tempered by sensibility and a humanistic mind—to plan, launch, and expand new business ventures independently or within an existing corporation.